7.3Overall Score

ProSupps Mr.Hyde is one of the most popular DMAA Free pre-workout on the market. I’m always trading supplements and samples with a bodybuilding friend of mine at the local Gold’s. He gave me a sample of Mr.Hyde and my workouts haven’t been the same since! I was curious to see why this pre-workout was kicking the trash outta my old one – which I will not name 😉 I spent countless hours scouring the internet, researching the ingredients in Mr.Hyde and finding all the research I could. I HAD to know why this pre-workout was just so much better than the rest. Here is what I found…

Mr Hyde Ingredients & Research

The first things that I noticed when I looked at Mr Hyde’s supplement facts (on the back of the label) is that they disclose ALL of the ingredients AND the amount of these ingredients. No “proprietary” blends. What you see is what you get. ProSupps has divided Mr.Hyde’s ingredients into three different matrices. They are the Strength Matrix, Caffeine Matrix and Intensity Matrix.

Strength Matrix

Beta Alanine – Beta alanine is a nonessential amino acid. This means it can be produced by the body whereas essential amino acids are acquired from food. Beta alanine combines with the essential amino acid histidine to create carnosine, which is found in high concentrations in brain and muscle tissue. Increasing carnosine concentration in the muscle tissue has been shown in numerous human studies to increase strength, muscular endurance and muscle mass.

Beta Alanine Research – Back in 2009, a study was performed to to evaluate the effects of combining beta-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in active college-aged men. The study concluded that beta-alanine supplementation may further enhance HIIT, improve endurance performance and lean body mass [1].

In 2006 a study published in Int J Sport Nutr Exerc Metab looked at the effect of Beta Alanine on 33 college football players over 10 weeks. The results of the study showed that the Beta-Alanine plus Creatine group gained significantly more muscle and lost more fat than the Creatine only or placebo group [2].

Creatine Hydrochloride – Creatine Hydrochloride, or Creatine HCl, is one of the newest forms of creatine. Creatine HCl is simply creatine with hydrochloride attached. There are many claims made about how Creatine HCl is superior to creatine monohydrate. Manufacturers boast about no loading, no bloating and water retention, no upset stomach, and no need to cycle off. These are just a few of the benefits.

Creatine Hydrochloride Research – Creatine Hydrochloride is 59 times more absorbent than creatine monohydrate. Studies also revealed that creatine hcl was more effective than Creatine ethyl ester and Kre-alkalyn. One study performed in the University of Manitoba 2009 [3] reported that creatine HCL is in fact easier for the body to absorb. This study was featured in the October 2009 Muscle & Fitness. The study concluded that:

  • Creatine HCL has an improved oral absorption rate when compared to creatine monohydrate.
  • Creatine HCL has been proven to be more water soluble than other forms of creatine.
  • Creatine HCL is more effective at raising creatine levels in the body than other forms of creatine.

L-Leucine – L-Leucine is one of the most beneficial amino acids that you can take. Whether you are trying to lose fat, build lean muscle, boost your workout performance, or all of the above, L-leucine will help you maximize all the efforts and hard work that you are putting in at the gym.

L-Leucine Research – Research has shown that the most important time to take l-leucine is during and after a training session. If l-leucine and the other branched chain amino acids are not present during this time, the body will go catabolic, breaking down its own muscle tissue to get them to burn as energy [4].

Agmatine Sulfate – Agmatine Sulfate is a metabolic byproduct of Arginine produced through a process called decarboxylation. Agmatine Sulfate provides many of the same benefits as Arginine supplementation, but seems to be WAY more effective.

Agmatine Sulfate Research – Agmatine Sulfate has been shown to inhibit Nitric Oxide Synthase (NOS), specifically iNOS and nNOS, leading to increased muscle pumps [5]. By effectively elevating NO and decreasing its breakdown, you will notice increased vasodilatation and nutrient delivery to the muscle cells can be maximized.

Agmatine Sulfate also boosts nutrient uptake by increasing muscle cell insulin sensitivity [6]. So agmatine not only helps you get the glucose and amino acids to the right place, it also opens the door and drives them right inside the muscle cell to enhance protein synthesis.

L-Citrulline Malate – L-Citrulline is a naturally occurring amino acid that is produced by the body but is also found in some foods like watermelon. Citrulline Malate stimulates phosphocreatine recovery after exercise, meaning faster recuperation between workouts, and muscles that are primed for growth and your next training session. It also helps open up veins and arteries to improve blood flow and reduce blood pressure.

L-Citrulline Malate Research – In a recent study published in 2010 in the Journal of Strength and Conditioning Research, participants used repeated sets of bench press exercises to muscular failure to test L-Citrulline Malate’s capacity to improve anaerobic performance. The study was of the highest scientific standard possible; it involved 41 male subjects and used a randomized, double-blind, 2-period crossover design.

The results of the study are very encouraging. Take a look! The number of reps performed significant increased by 52.92%! Every participant had an increase in reps! Participants also reported an average decrease of 40% in muscle soreness at 24 hours and 48 hours after the pectoral training session when supplementing with L-Citrulline Malate prior to the workout [7].

Caffeine Matrix

Caffeine Anhydrous – Caffeine Anhydrous is simply a form of caffeine that contains less water. Normal caffeine contains roughly 8.5% water while caffeine anhydrous contains 0.5% water. It is used in supplements because it is an effective fat burner and energy booster.

Caffeine Anhydrous Research – There has been tons and tons of caffeine studies done in regards to its effect on sports performance. A study performed in 1995 showed that caffeine helped the body boost its metabolic rate and increase energy expenditure [8]. This allows your body to burn more calories and unwanted fat. There has also been a few studies that indicate that caffeine in pre-workout supplements like Mr.Hyde may lead to increased upper body strength [9, 10, 11].

Caffeine Citrate – Caffeine Citrate, aka Cafcit, is made by mixing citric acid with calcium to form a type of salt. It provides the same benefits as caffeine anhydrous but due to the citrate bond its effects are felt much faster. So when you take Mr.Hyde you will be ready to hit the weights hard and with intensity and focus.

Caffeine Citrate Research – See Caffeine Anhydrous Studies Above.

Infinergyâ„¢ DiCaffeine Malate – Infinergyâ„¢ represents a precise combination of Caffeine and Malic Acid into an ionic bonded compound. By combining the well-established properties of Caffeine and Malic Acid, Infinergyâ„¢ offers a multi-dimensional ingredient that not only optimizes energy levels, but also stimulates thermogenisis while promoting mental focus.

Infinergy DiCaffeine Malate Research – See Caffeine Anhydrous Studies Above.

Infinergyâ„¢ Matrix

Pikatropin (Pikamilon) – Pikatropin, perhaps better known as Pikamilon, is a cognitive enhancer that promotes greater blood flow to the brain and reduces mental fatigue. Pikatropin is able to enhance cognitive and analytical function as well as hand to eye coordination. This allows you to have sharp focus and determination during exercise.

N-Methyl Tyramine – N-Methyl Tyramine is the methylated version of L-Tyramine. N-Methyl Tyramine can be found in nature from plants such as barley and Citrus aurantium. It releases norepinephrine, giving you instant energy when you need it. t is also known to block a receptor known to promote fat storage. If you want enhanced alertness and energy that will help you get the toughest workouts, N-Methyl Tyramine will help you fight the effects of muscle fatigue!
N-Methyl Tyramine Research – N-Methyltyramine HCL has clinically proven to work primarily as an alpha2-adrenoceptor antagonist[12]. This allows you to burn fat.

In a recent study, over the course of 2 hours N-Methyl Tyramine boosted the production of norepinephrine by the heart by a bit over 35%, compared to control.[13]

Hordenine – Hordenine is closely related to Tyramine, and is a naturally occurring compound found mainly in grasses and grains. Hordenine is a stimulant. The main benefit of Hordenine is said to be its potential to assist the release of fat from fat cells for usable energy. Another reported benefit of Hordenine is that it promotes slow digestion of food which allows you to feel “full” for a longer period of time. Feeling full will hopefully reduce any cravings you have reducing your overall caloric intake.

Hordenine Research – Human studies have shown that when a supplement containing hordenine was given to a group of trained men, it caused a significant increase in noradrenaline levels, reaching a peak at 90 minutes after ingestion, providing an increase exercise performance [14].

A separate study has shown that when given a supplement containing hordenine, participants experienced a significant increase in energy usage and lipolysis compred to the placebo group [15].

Yohimbe Bark Extract – Yohimbine was one of the first products found in the market as an alpha-2 antagonist which means that it blocks alpha-2 receptor stimulation. Once blocked, the body would be able to release more norepinephrine. Another benefit to blocking the alpha-2 receptors with another alpha-2 antagonist is that it prevents the formation of new fat tissues. Losing weight will be easier if your body can’t make excess adipose tissues.

Yohimbe Bark Extract Research – There has been tons of research done over the past 2 decades on Yohimbe. Back in 2006, a study was performed to determine the effects of yohimbine supplementation on body composition and exercise performance in professional soccer players. The study showed that yohimbe leads to fat loss. In the study, the ercentage of body fat significantly decreased in the yohimbine group after the supplementation protocol (9.3 +/- 1.1 vs. 7.1 +/- 2.2%; p < 0.05). Fat mass was significantly lower in the yohimbine versus placebo trial at post-supplementation assessment (7.1 +/- 2.2 vs. 9.2 +/- 1.9%; p < 0.05).

Rauwolfia Vomitoria Root Extract (90% Alpha-Yohimbine) – Rauwolscine aka Alpha Yohimbine is a stereoisomer of yohimbine. This different chemical arrangement creates some pretty significant differences between Rauwolscine and Yohimbine. Rauwolscine is an Alpha-2 receoptor antagonist. This means it does not stimulate the Alpha receptors, but that it suppresses or disables them triggering lipolysis and allowing your body to breakdown fatty tissue.

Rauwolfia Vomitoria Root Extract Research – Research has proven that this ingredient is a very potent antagonist of the alpha-2 adrenergic receptors.[16]

How Do You Take Mr.Hyde?

You should take one scoop of Mr.Hyde 15 – 30 minutes before you workout. Each bottle of Mr.Hyde contains 40 servings and comes in either fruit punch or watermelon flavors. As with any preworkout, you should assess your tolerance and pay attention to ProSupps suggested use. They say no more than one scoop every day.

Final Thoughts on Mr. Hyde

I am currently taking Mr. Hyde (watermelon) and have been taking it for one week. First off, it mixes very good and tastes great. I haven’t noticed any stomach sensitivity or gut aches. I do notice that I get an instant shot of energy, not so much that I’m trembling, and that my energy levels and ability to focus remain strong throughout my workout sessions. I highly recommend trying this preworkout!

This is one man’s opinion. What really matters is how well it works for all of you. Please use our form below to share what your experiences have been with Mr. Hyde. Please include other product(s) you have used, side effects, benefits, dosage, and let us all know if you think Mr. Hyde is a good value or not.


[1] – J Int Soc Sports Nutr. 2009; 6: 5. “Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial.”

[2] – Int J Sport Nutr Exerc Metab. 2006 Aug;16(4):430-46.”Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes.” Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J.

[3] – Donald W. Miller, Oral Bioavailability of Creatine Supplements: Is There Room for Improvement?

[4] – Norton LE, & Layman DK. (2006). Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. The Journal of Nutrition. 136(2), 533S-537S.

[5] – Amino Acids 38(2): 393-403. Ahn, S. K., S. Hong, et al. (2011). “Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.”

[6] – Ko WC, Liu IM, Chung HH, Cheng JT. 2008. Activation of I(2)-imidazoline receptors may ameliorate insulin resistance in fructose-rich chow-fed rats. Neurosci Lett. Dec 19;448(1):90-3.

[7] РP̩rez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research. 2010;24(5):1215-1222.

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[14] – Bloomer et al (2009a), Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men. Journal of the International Society of Sports Nutrition, 6 (online)

[15] – Bloomer et al (2009b), Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study. Lipids in Health and Disease, 8 (online)

[16] – erry BD, U’Prichard DC. (3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. (1981)

About The Author

Brian E. is from southern California and has worked for names like GNC and Vitamin Shoppe as a supplement expert and consultant. He currently lives in Utah and is studying marketing.

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