• Burns Fat
  • DMAA Replacement
  • Heavy stimulant based
8.6Overall Score

If you’ve waved your hand dismissively at other fat burners deciding they aren’t the thermogenics you’re looking for, VPX might have what you need with their new MD2 Meltdown.

One of the big ingredients they’re promoting in here and some of their other new fat burners is the compound theacrine, which does actually have some research behind it. In this review I’ll not only breakdown theacrine, but everything else you need to know before buying MD2 Meltdown.

Caffeine for Days

VPX has built a reputation and gained a steady following for their caffeine suffused supplements, and MD2 Meltdown is no exception. A 2 pill serving has 300 mg of caffeine. So depending on your stimulant tolerance, you may just want to take 1 pill to cut the caffeine down to 150 mg.
MD2 Meltdown Reviews

Theacrine Time

Theacrine is an alkaloid which shares a similar structure with caffeine. What’s more, theacrine is shown to have the same energy boosting benefits as caffeine, without the tolerance buildup.
Theacrine is also linked to a number of other benefits including pain reduction, anti-stress effects, and and enhancd dopaminergic signaling.[1]

DMAA Replacement

Another unique compound you’re going to come across in MD2 Meltdown is 4-Amino-2-Methylpentane Citrate. This compound is being touted as a replacement for DMAA, and reputedly has the same benefits of enhanced thermogenesis, better cognitive ability and reduced body fat.

Rounding out MD2 Meltdown’s formula is a yohimbe complex with three different yohimbe derivatives. Yohimbe acts as an alpha-2 receptor antagonist, enhancing lipolysis by releasing more fatty acids to be burned as energy.[2]

My MD2 Meltdown Experience

I took MD2 first thing in the morning before breakfast. I’m not very sensitive to stimulants, but started off with one pill just in case. Like other fat burners, make sure you have some food on hand.
MD2 Meltdown VPX
No matter your tolerance, there’s a chance you will get jittery if you don’t eat something 20-30 minutes after taking a fat burner.

I ate breakfast about 20 minutes or so after taking MD2, and definitely felt my core temperature heating up. The energy from one pill was perfect for me, but again that’s very subjective and will ultimately depend on your individual stimulant tolerance.

Overall this is a great fat burner, and pretty much does what you want it to as long as your nutrition is on point and you’re consistent with your workouts.

Final Wrap Up

MD2 is being sold in 70 and 100 count bottles, and the average online prices are $35 and $55 respectively. If you’re looking for something new to try, or just want to fill the void left by the DMAA ban, I think MD2 Meltdown is a great fat burner.

Like I mentioned above, it has pretty much everything you’re looking for out of a fat burner.

[1]Feduccia AA, et al. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacol Biochem Behav. (2012)
[2] McCarty MF. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis Med Hypotheses. 2002 Jun;58(6):491-5.

About The Author

Brian E. is from southern California and has worked for names like GNC and Vitamin Shoppe as a supplement expert and consultant. He currently lives in Utah and is studying marketing.

4 Responses

  1. Niwali Test O Boost

    I love this gym . I discovered not long ago when I was on a quest 2 months looking new gyms . Even after joining I was still in search of the gyms , but this place quickly put my mind at ease . It has everything I need and more . It actually has people in it that raise too. No this pompous gym where everyone will sit and look skinny talk about how they are ultimately going to training after having their fruit smoothie . Blood sweat and tears have been spilled in this gym . The computer is a little older and the gym has more of a feeling of sandy elevation than the other gyms in the country club, which is exactly what I was looking for . People get serious here and make changes and earnings . This is my home away from home when I’m not working . Valencia Street Muscle is the way to go . Oh by the way … the prices are great !

  2. Niwali Test O Boost

    No matter how many roads you put over your muscles a workout. Work your body is to repair while you sleep. It is natural! Now this does not mean go and do the same exercises the next day and came to the same muscles that actually is overtraining. 2-3 days max is all you need to rest before reaching the same muscle fibers again. But be sure to take a week off at some point because your body will get used to the intensity and adapt. Your body can and will adapt to the workout / cut the intensity of their inflict on him. that

  3. Niwali Test O Boost

    I lost 10 pounds of water weight and probably 2% body fat

    When I was 155 my arms are 13.5 (flexed)

    and there is the same size 144-145 13.5

    And when I have lost water weight calves grew from 12 inches to 14 inches

    So there is no muscle mass is lost, my waist went from 31 inches to 29 inches today that is all that has changed.


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